Bilsab
CAGLAR LAB
The major goal of our research is to understand the neuronal and molecular mechanisms that govern binge eating
Research
Several mechanisms exist in the brain to detect and respond to disruptions in the balance between satiety and hunger. However, it is possible for these mechanisms to be impaired, which in turn may lead to various disorders and abnormal behaviors, such as binge eating. Binge eating is defined as eating much more than one can consume in a short period of time due to a satiety deficit. To elucidate the underlying neuronal and molecular mechanisms that trigger binge eating, our lab utilizes wide range of cutting-edge technologies. By using recombinase driver mice and recombinase-dependent AAVs that express a variety of genetically encoded tools, the major goals of Caglarlab are to:
1-) Map neuronal connectivity and establish wiring diagrams
2-) Control the firing rate of neurons in vivo to determine their functions in the regulation of binge eating
3-) Obtain insights into the response of neurons in vivo to binge eating
Thus, the accumulation of knowledge in our lab will provide new principals for appetite regulation to develop novel therapeutic agents to combat binge eating and its related disorders.